Clearances for the block skirt, wrist pin, PTV, and everything else exist in every motor. Doesn't matter what you wanna put in it, a proper build will check it and do machine work as needed.
It all depends on the math and the clearances. There is no automatic do this and you have to do this. Some brands have bigger or smaller castings and the way some cams are cut they just naturally offer more room.
You need to have to start picking the actual parts to be used before you can plan to do any of that kind of machine work or spend extra time/money looking at a different cam.